Descriptive analysis of PD-L1 expression in non-small cell lung carcinoma biopsies: two -year experience in a tertiary Hospital

Authors

DOI:

https://doi.org/10.32932/gecp.2021.07.014

Keywords:

PD -L1, non-small cell carcinoma, lung

Abstract

Introduction: The expression of PD-L1 as a predictive marker of response to treatment of non-small cell lung cancer (NSCLC) allows the identification of patients most likely to benefit from treatment with inhibitors of immune checkpoints. The main objective of this study was to determine the PD-L1 positivity/negativity rates of biopsies diagnosed with NSCLC during the year 2017 and 2018 at CHUPorto and compare with the predicted rates.
Materials and methods: All biopsies of lung, bronchus or pleura diagnosed with primary epithelial neoplasia were surveyed and categorized according to the age and sex of patients, the reported diagnosis, the level of expression of PD-L1 and the mutational study.
Results: Of the 262 cases identified, 57% were diagnosed with adenocarcinoma, 26% with squamous cell carcinoma, 11% with neuroendocrine neoplasia and 6% with others. PD-L1 expression was evaluated in 215 biopsies out of 229 recorded with the diagnosis of NSCLC. Of these 215 cases, 54% were negative, 26% showed mild to intermediate positivity and 20% high positivity for PD-L1.
Discussion and conclusion: The evaluation of PD-L1 expression in lung cancer biopsies is an essential tool for defining the treatment of these patients. The values of PD-L1 expression described here in the clinical practice of CHUPorto tend to be more negative than those described in the original clinical trial, but similar to those described by real-life studies. Given the impact that the expression of PD-L1 has on the management of patients with NSCLC in daily clinical practice, it is important to know our reality. As future perspectives, we consider important the correlation analysis of PD-L1 expression with the results of treatment with inhibitors of immune checkpoints.

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References

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Published

2025-01-05

Issue

Section

Retrospective Article

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